Structural correlates of rotavirus cell entry
WebSep 19, 2024 · Also, a better understanding and validation of Rotavirus entry factors as well as the systematic monitoring of dominant strains could assist in tailoring vaccines to individual’s needs. Another aspect that could improve vaccine efficiency is targeting to M cells, for which new ligands could potentially be sought. WebDec 22, 2024 · Rotavirus Cell Entry. Upon entry in the body, viruses infect mucosal epithelial cells and replicate in cell cytosol. There are two pathways of viral cell entry including direct entry at the epithelial plasma membrane, or via epithelial endocytosis (22, 23).Thus, the molecular interactions between the virus and target-cell receptors influences the viral …
Structural correlates of rotavirus cell entry
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WebVersion of Record. dc.contributor.author: Abdelhakim, Aliaa H. en_US: dc.contributor.author: Salgado, Eric N. WebThere are three ways that a virion with VP4 can enter a host cell. One way is that VP4 forms 60 spikes at the surface; VP7 is cleaved and opens for VP4 to enter to form spikes and lyse. Another way is direct penetration of the virion across the plasma membrane and endocytosis. Another way is cleavage of VP4 to products VP8 and VP5 by proteolytic …
WebSep 11, 2014 · Structural and mutational evidence suggests that rotaviruses penetrate by disruption of an endocytic membrane, driven by a … WebPublications. 2024. Kuraoka, M., Curtis, N.C., Watanabe, A., Tanno, H., Shin, S., Ye, K., Macdonald, E., Lavidor, O., Kong, S., Von Holle, T., Windsor, I., Ippolito ...
WebSep 1, 2000 · Growth of rotaviruses in continuous human and monkey cell lines that vary in their expression of integrins Microbiology Society Volume 81, Issue 9 Other Free Growth of rotaviruses in continuous human and monkey cell lines … WebPubMed
WebAn in vitro replication system for RVs in permanent cell lines was developed in 1982 and expanded to replication in intestinal organoids in 2015. However, the details of rotavirus (RV) entry into cells and particle maturation mechanisms at the molecular level remain incompletely understood.
WebStructural and mutational evidence suggests that rotaviruses penetrate by disruption of an endocytic membrane, driven by a conformational change in one of its outer-surface … instant pot ham hock bean soup recipeWebLarge nanodiscs offer a versatile tool to study membrane interaction of viruses which can solve several questions about virus entry such as mechanism of membrane penetration, steps in disassembly of virus particles, conformational changes, and the regulatory role played by host cell surface receptors. jira find all child issues of a queryWebNov 9, 2024 · The immune correlates of protection against rotavirus reinfection and recovery from infection are poorly understood, although rotavirus-specific … jira find tickets you worked onWebMay 1, 2006 · Rotaviruses recognize several cell-surface molecules, including the α 2 β 1 integrin, and the processes of rotavirus cell attachment and entry appear to be multifactorial. The VP5* subunit of the rotavirus spike protein VP4 contains the α 2 β 1 ligand sequence Asp–Gly–Glu at residues 308–310. Binding to α 2 β 1 and infectivity of … jira find issues i\u0027m watchingWeb(2014) Abdelhakim et al. PLoS Pathogens. Cell entry by non-enveloped viruses requires translocation into the cytosol of a macromolecular complex—for double-strand RNA … instant pot ham hock recipesWebCell entry by non-enveloped viruses requires translocation into the cytosol of a macromolecular complex—for double-strand RNA viruses, a complete subviral particle. ... Structural Correlates of Rotavirus Cell Entry. Abdelhakim A; Salgado E; Fu X; et al. See more; PLoS Pathogens (2014) 10(9) DOI: 10.1371/journal.ppat.1004355. 22 Citations ... jira find archived issuesWebApr 20, 2024 · The rotavirus genome is made up of 11 dsRNA segments, coding for 6 structural proteins (VP1–VP4, VP6, and VP7) and 6 nonstructural proteins (NSP1–NSP6) [ 4 ]. The TLP is the infectious form of the virus that attaches to and enters into host cells. jira find epics with no open stories