WebN2 - Oncostatin M (OSM) is a multifunctional cytokine found in a variety of pathologic conditions, which leads to excessive collagen deposition. Current studies demonstrate that OSM is also a mitogen for fibroblasts and has an anti-inflammatory action. WebInterleukin-4 antagonizes oncostatin M and transforming growth factor beta-induced responses in articular chondrocytes
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WebNov 1, 2024 · Oncostatin M (OSM), a pleiotropic proinflammatory cytokine produced by activated T lymphocytes and monocytes, regulates a variety of biological processes via the JAK/signal transducer and activator of transcription (STAT), phosphatidylinositol 3-kinase (PI3K), and mitogen-activated protein kinase (MAPK) pathways [1], [2]. Oncostatin M, also known as OSM, is a protein that in humans is encoded by the OSM gene. OSM is a pleiotropic cytokine that belongs to the interleukin 6 group of cytokines. Of these cytokines it most closely resembles leukemia inhibitory factor (LIF) in both structure and function. As yet poorly defined, it is proving … See more The human form of OSM was originally isolated in 1986 from the growth media of PMA treated U-937 histiocytic lymphoma cells by its ability to inhibit the growth of cell lines established from melanomas and other solid tumours. … See more Receptors for OSM can be found on a variety of cells from a variety of tissues. In general cells derived from endothelial and tumour origins express high levels of OSM receptors, whereas … See more Signalling by type I and type II OSM receptors have now been shown to be qualitatively distinct. These differences in signaling character, in addition to the tissue distribution profiles of OSMRb and LIFRb, offer another variable in the distinction between … See more • Oncostatin M receptor See more Primary sequence analysis of OSM allocates it to the gp130 group of cytokines. OSM most resembles LIF, bearing 22% sequence identity … See more Oncostatin M triggers the formation of receptor complexes by binding to receptors via two binding sites named site II and site III. The nomenclature of these sites is taken by … See more The role of OSM as an inflammatory mediator was clear as early as 1986. Its precise effect on the immune system, as with any cytokine, … See more northern lights lodge ely mn
Oncostatin M - Wikipedia
WebOct 29, 2003 · Oncostatin M (OSM) is a multifunctional cytokine that belongs to the Interleukin (IL)-6 subfamily. Among the family members, OSM is most closely related … WebOncostatin M (OSM), as a member of the Interleukin-6 family cytokines, plays a significant role in inflammation, autoimmunity, and cancers. It is mainly secreted by T … WebVirginia Tech. May 2024 - Jul 20243 months. Blacksburg, Virginia. • Examined splash dispersal of harmful algal blooms in freshwater systems using principles of fluid … northern lights lodge ontario