Cisplatin pubmed

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August undefined, 2024

WebNov 20, 2016 · Whole-exome sequencing or targeted exon-capture-based sequencing was performed on 180 tumors. Patients were categorized as cisplatin sensitive or cisplatin resistant by using a combination of postchemotherapy parameters, including serum tumor marker levels, radiology, and pathology at surgical resection of residual disease. WebJan 28, 2024 · In this study, we sought to provide a comprehensive review of the current state of the science highlighting the use of cisplatin in cancer therapy, with a special emphasis on its molecular mechanisms of action, and treatment modalities including the combination therapy with natural products.

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WebCisplatin is a platinum chemotherapeutic used in a variety of malignancies. The … WebGemcitabine and cisplatin chemotherapy is an active combination in the treatment of platinum-resistant ovarian and peritoneal carcinoma Invest New Drugs. 2004 Nov;22 (4):475-80. doi: 10.1023/B:DRUG.0000036690.14585.a3. Authors Devansu Tewari 1 , Bradley J Monk , Mark Hunter , Camille A Falkner , Robert A Burger Affiliation raymond lo wsp

Profiling of signaling molecules in four different human prostate ...

WebGemcitabine and cisplatin plus durvalumab are being evaluated in the phase 3, TOPAZ … WebSep 15, 2024 · Cisplatin is the prototype platinum coordination complex classified as an … WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 cells, either induced by cisplatin or by UV light, can lead to further apoptotic death in … raymond lowman ferrum va

Cisplatin pubmed

Cisplatin: a review of toxicities and therapeutic applications

WebWe aimed to evaluate cisplatin pharmacokinetics (PK) and the exposure to unbound … WebThe platinum analogues, cisplatin and carboplatin, are among the most widely used chemotherapeutic agents in oncology. Both agents have a broad spectrum of clinical activity in numerous malignancies including gynaecological cancers, germ cell tumours, head and neck cancer, thoracic cancers and bladd …

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WebSep 3, 1991 · After a preliminary dose-finding study involving 12 patients with advanced or locally recurrent head and neck cancer, 27 patients were treated on a phase II protocol, using fluorouracil 350 mg/m2/d by continuous intravenous (IV) infusion over 5 days, followed on the sixth day by a 2-hour IV infusion … WebCisplatin (Platinol) has an important dose-response relationship in ovarian cancer. We …

WebJun 1, 2024 · After completion of gemcitabine and cisplatin, 1500 mg of durvalumab or … WebAug 8, 2010 · Cisplatin is one of the most effective anticancer agents widely used in the …

WebCisplatin and MD-805 were loaded in the films by casting the polymer solution containing the drugs. Fractions of the drugs released from the PLA-CL films were governed by the initial loading, the film thickness, and the polymer molecular weight. The drug release profiles obeyed the classical Fickian diffusion equation at least in the early ... WebSep 18, 2024 · Cisplatin is a medication used to manage and treat solid tumors and hematologic malignancies. It is in the alkylating agent class …

WebJul 1, 2024 · Background/aim: Cisplatin combined with pemetrexed disodium heptahydrate (pemetrexed) is considered the standard treatment for patients with advanced, non-squamous, non-small-cell lung cancer. However, its growth-inhibitory effects on KRAS-dependent lung cancer as monotherapy and combination therapy are not well understood.

WebCisplatin / metabolism Cisplatin / pharmacology* Cisplatin / therapeutic use Combined … raymond loyaWebDec 1, 2024 · Methods. In this open-label, randomized, phase III study, newly diagnosed patients with advanced NSCLC were initially randomized (R1, 1:1) to receive first-line treatment with cisplatin 75 mg/m 2 plus docetaxel 75 mg/m 2 (DC75) or 60 mg/m 2 (DC60) for up to 4 cycles. Patients without progression were further randomized (R2, 1:2) to best … raymond loyer imdbWebCisplatin-resistant bladder cancer overexpresses particular sugar chains compared with chemotherapy-naïve bladder cancer. Using a recombinant protein from the malaria parasite Plasmodium falciparum, we can target these sugar chains, and our results showed a significant antitumor effect in cisplatin- … raymond loy edmonds waWebIntroduction: Cisplatin, a platinum-based antineoplastic agent, is the cornerstone for the … raymond lowry teen momWebOct 7, 2024 · Cisplatin is one of the most widely used chemotherapeutic drugs in the … raymond lo year of the tiger 2022WebCisplatin and MD-805 were loaded in the films by casting the polymer solution containing … raymond lozon twitterWebCisplatin or (SP-4-2)-diamminedichloridoplatinum(II) is one of the most potential and … raymond loza