Cisplatin cardiomyopathy

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August undefined, 2024

WebMar 17, 2024 · Cardiotoxicity is defined as any heart injury (functional or structural) related to cancer treatment, taking into consideration chemotherapy, radiotherapy … WebOct 1, 2013 · Chemotherapy may induce entire spectrum of cardiac pathology. Cisplatin (CDDP) is a widely used chemotherapeutic agent and its use is limited by its wide range of toxicities, most common being renal and neurotoxicity. Cardiotoxicity of cisplatin is less common and may range from silent and symptomatic arrhythmias to cardiomyopathy …

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WebAcute clinical syndromes associated with cisplatin infusion include chest pain, palpitations, and, occasionally, elevated cardiac enzymes indicative of myocardial infarction (MI). 16 … WebAug 1, 2012 · Traditional and novel chemotherapy agents can damage the heart or peripheral blood vessels, or cause problems with clotting or blood lipids. Some … the place at westover hills

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WebJun 23, 2014 · Cardiomyopathy after the use of gemcitabine monotherapy is extremely rare; and only one such case has been reported in detail previously. ... Barton C, Ghahramani P, Hirsh V: Randomized phase II trial of gemcitabine-cisplatin with or without trastuzumab in HER2-positive non-small-cell lung cancer. Ann Oncol. 2004, 15: 19-27. … WebCytostatic antibiotics of the anthracycline class are the best known of the chemotherapeutic agents that cause cardiotoxicity. Alkylating agents such as cyclophosphamide, ifosfamide, cisplatin, carmustine, busulfan, chlormethine and mitomycin have also been associated with cardiotoxicity. WebFeb 21, 2024 · Among the serious complications that have been reported are: ● Arrhythmias ● Heart failure ● Myocardial necrosis causing a dilated cardiomyopathy the place at spanish trail apartments tucson

Cardiotoxicity of cisplatin-based chemotherapy in advanced non …

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WebMay 4, 2024 · Signs and symptoms of dilated cardiomyopathy may include: Fatigue. Shortness of breath (dyspnea) during activity or while lying down. Reduced ability to exercise. Swelling (edema) in the legs, ankles, … WebApr 11, 2024 · Cisplatin is a widely used chemotherapeutic agent for treatment of various cancers. However, treatment with cisplatin is associated with drug resistance and several adverse side effects such as nephrotoxicity, reduced immunity towards infections and … the place at the beachWebCisplatin-induced cardiotoxicity is a well describe effect with a low incidence. Supraventricular arrhythmias and coro-nary artery disease are the main cardiac effects. ... Cardiotoxicity secondary to cisplatin administration manifests as both delayed effects (mainly as chronic ischemic cardiomyopathy and arterial hypertension) and acute ... the place at westover hills complaints

"WebChemotherapeutic drugs can cause cardiac toxicities such as cardiomyopathy, arrhythmia, and cardiovascular disease. The well-known side effects of cisplatin are nephrotoxicity, nausea, vomiting, and electrolyte imbalance. Cardiotoxicity induced by cisplatin is rare, and its pathophysiology is unknown. " - Cisplatin cardiomyopathy

Cisplatin cardiomyopathy

Cisplatin and Congestive cardiomyopathy, a phase IV clinical …

WebOct 6, 2024 · The following are common signs of cardiomyopathy: Trouble breathing when you’re active or resting. Some people might also need to sleep sitting up or with many pillows under their head to help them … WebCardiotoxicity has been well documented as a side effect of cisplatin (CDDP) treatment. The inflammatory response plays a crucial role in the pathological process of CDDP-induced cardiotoxicity. Wogonin is a natural flavonoid compound that possesses cardioprotective and anti-inflammatory qualities.

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WebJan 10, 2011 · Combinations of cisplatin with other anticancer drugs as methotrexate, 5-fluorouracil, bleomycin and doxorubicin are associated with lethal cardiomyopathy ( … WebJun 1, 2024 · Cisplatin (CP)-induced nephrotoxicity is widely accepted as a model for acute kidney injury (AKI). ... We showed that old mice had more severe kidney injury and cardiomyopathy after exposure to ...

WebFeb 2, 2024 · Learn about the potential side effects of pemetrexed. Includes common and rare side effects information for consumers and healthcare professionals. WebApr 21, 2024 · If you’re receiving carboplatin or cisplatin chemotherapy, talk to your doctor about the risks to your hearing. Heart problems Chemotherapy can lead to high blood …

WebCisplatin can induce direct myocardial toxicity leading to atrial fibrillation whereas the potential of myocardial toxicity is amplified when the drug is administered in … WebApr 2, 2024 · Cardiomyopathy (kahr-dee-o-my-OP-uh-thee) is a disease of the heart muscle that makes it harder for the heart to pump blood to the rest of the body. Cardiomyopathy can lead to heart failure. The main types …

WebAlthough cisplatin (cisPt) is one of the most often used cytotoxic drugs in the treatment of cancer, its clinical application is associated with nephrotoxicity 掌桥科研一站式科研服务平台

WebWARNING: CARDIOMYOPATHY, INFUSION REACTIONS, EMBRYO-FETAL TOXICITY, and PULMONARY TOXICITY See full prescribing information for complete boxed warning Cardiomyopathy: trastuzumab products can result in subclinical and clinical cardiac ... Cisplatin was administered at 80 mg/m on Day 1 and the the place at the fountains the place at which the bridgeWebDec 6, 2024 · weakness in the arms, hands, legs, or feet Less common Blood in the urine or stools difficult or labored breathing pinpoint red spots on the skin shortness of breath (severe) slow heartbeat tightness in the chest wheezing Incidence not known Anxiety blue lips, fingernails, or skin difficult or troubled breathing fainting fast heartbeat side effects of stopping proliaWebCisplatin: 70 mg/m 2 IV: Dilute with 250 mL NS* and administer over 60 minutes. Do not administer with aluminum needles or sets. Day 2: Pretreatment considerations: Emesis … side effects of stopping sinemet abruptlyWebJul 23, 2024 · Clinical implication of Cisplatin (cis-dichlorodiammine-platinum (II), CP) is restricted owing to augmented oxidative stress and apoptosis that have been involved in cardiac injury. Cisplatin usage is also associated with the cardiotoxicity including arrhythmia, myocarditis, cardiomyopathy and congestive heart failure [1,2,3,4,5]. the place at westover hills apartmentsWebJan 10, 2011 · Cisplatin-induced cardiotoxicity: Mechanisms and cardioprotective strategies. Increased oxidative stress and apoptosis have been implicated in the cardiotoxicity that … side effects of stopping protonixWebJan 1, 2013 · Patients receiving cisplatin-based chemotherapy may experience coronary artery diseases, arrhythmias, and cardiomyopathy 3). Moore et al. have reported cases of arterial thrombosis with subsequent ... side effects of stopping probiotics